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The importance of effervescent packaging

Aug 13 , 2020

The main design of the effervescent tablet tube is the packaging of the effervescent tablet, which is moisture-proof and anti-damage. When the effervescent tablet is packaged early, it is the most prominent dryness of the package. There is a spiral spring to prevent the effervescence from being damaged during transportation.


The importaance of effervescent packaging

effervescent tubes


Precautions for the production and packaging of effervescent tablets:

1. Do not make the acid and alkali together with the main drug during granulation, because the general acid or alkali will affect the stability of the drug and may lead to unqualified degradation products.

2. The disintegration degree is not more than 5 minutes according to the pharmacopoeia, which is relatively easy to achieve. Our internal control standard is 90 seconds. When granulating, use a binder with a low viscosity and use a high concentration of ethanol to granulate (such as absolute ethanol), so that it dries quickly, the particles are relatively loose, and the degree of disintegration is easily qualified. But pay attention to the friability, the pharmacopoeia stipulates no more than 1%. (But it seems that a special application can be made for effervescent tablets, which should be relaxed appropriately.) Finally, acid and alkali are added as additional auxiliary materials in the final mixing.

3. Be careful not to store the prepared pellets for too long, and control the humidity.

4. The humidity should also be controlled during tablet pressing to prevent water absorption.

5. As for packaging, you can choose double aluminum packaging or high-density polyethylene bottle or PP plastic bottle packaging that is not easily permeable to water and oxygen to ensure its stability.


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